Melanoma breakthrough: Natural fruit and vegetable substance stops skin cancer cells

Not all skin cancers are life-threatening but there is one form — melanoma —  which is difficult to treat successfully and can be deadly. A type of cancer  that begins in melanocytes (cells that make the pigment melanin), it can start  in a mole (skin melanoma), but can also begin in other pigmented tissues, such  as in the eye or even the intestines. According to the National Cancer  Institute, almost 77,000 new cases of melanoma are expected to be diagnosed  in the US this year.

fruit and vegetables
Currently, there is no single therapeutic agent or  combination treatment available to treat all melanomas. About 9,480 Americans  are predicted to die in 2013 from this malignancy which can spread throughout  the body. But there’s good news on the research front about the disease. For the first time, scientists have demonstrated that a natural substance, gossypin, found in vegetables and fruits can halt melanoma cells – and they say  they know why.
“We identified gossypin as a novel agent with dual  inhibitory activity towards two common mutations that are the ideal targets for  melanoma treatment,” Texas Biomed’s Hareesh Nair, Ph.D., who headed the  research, said in a media statement. “Our results indicate that gossypin may  have great therapeutic potential as a dual inhibitor of mutations called  BRAFV600E kinase and CDK4, which occur in the vast majority of melanoma  patients.”
Nair added that his research team’s findings “… open a new  avenue for the generation of a novel class of compounds for the treatment of  melanoma.”

Natural substance blocks growth of melanoma cells

For the new study,  just published in the journal Molecular Cancer Therapeutics, Nair and his  colleagues worked with human melanoma cells in the lab. They found that gossypin  inhibited human melanoma  cell proliferation in melanoma cell lines that harbor the two mutations,  possibly by directly binding with them.
What’s more, the veggie and  fruit derived substance inhibited the growth of a variety human melanoma  cells. In addition, in animal experiments using mice transplanted with human  melanoma cell tumors, gossypin treatment for 10  days reduced tumor volume and increased survival rate.
Nair’s team is now  working to understand how the body absorbs gossypin and how it is metabolized.  In the media statement, the researchers noted discussions are underway with the  Cancer Therapy & Research Center at the University of Texas Health Science  Center about testing gossypin in melanoma patients.

Editor’s note:  NaturalNews is opposed to the use of animals in medical experiments that expose  them to harm. We present these findings in protest of the way in which they were  acquired.